Multiple-dose pharmacokinetics of ceftibuten in healthy volunteers
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چکیده
منابع مشابه
Pharmacokinetics of single- and multiple-dose teicoplanin in healthy volunteers.
Teicoplanin, an investigational glycopeptide antibiotic related chemically and microbiologically to vancomycin, has in vitro and in vivo activity against gram-positive aerobic and anaerobic bacteria. We compared the single- and multiple-dose pharmacokinetics of intravenous teicoplanin in healthy volunteers. Serum and urine samples were collected for 35 days after single-dose (3 mg/kg) and 72 da...
متن کاملComparative pharmacokinetics of oral ceftibuten, cefixime, cefaclor, and cefuroxime axetil in healthy volunteers.
STUDY OBJECTIVE To compare the pharmacokinetics of ceftibuten, cefixime, ceturoxime axetil, and cefaclor after oral administration. DESIGN Randomized, four-period, crossover study. SETTING Hospital-based clinical research center. SUBJECTS Healthy adult men and women volunteers. INTERVENTIONS Single 400-mg doses of cefixime and ceftibuten, and 500-mg doses of cefuroxime axetil and cefacl...
متن کاملSingle-dose and multiple-dose pharmacokinetics of zaltoprofen after oral administration in healthy Chinese volunteers
Zaltoprofen, a propionic acid derivative of non-steroidal anti-inflammatory drugs, has strong inhibitory effects on actue and chronic inflammation. A randomized, dose-escalating study was conducted to evaluate the pharmacokinetics of single and multiple oral doses of zaltoprofen in 12 healthy Chinese volunteers. Pharmacokinetics was determined from serial blood samples obtained up to 24 h after...
متن کاملSingle dose pharmacokinetics of oral artemether in healthy Malaysian volunteers.
AIMS To determine the pharmacokinetics of artemether (ARM) and its principal active metabolite, dihydroartemisinin (DHA) in healthy volunteers. METHODS Six healthy male Malaysian subjects were given a single oral dose of 200 mg artemether. Blood samples were collected to 72 h. Plasma concentrations of the two compounds were measured simultaneously by reversed-phase h.p.l.c. with electro-chemi...
متن کاملSingle and multiple dose pharmacokinetics and tolerability of HX-1171, a novel antioxidant, in healthy volunteers
BACKGROUND HX-1171 (1-O-hexyl-2,3,5-trimethylhydroquinone) is a promising antioxidant with therapeutic potential for hepatic fibrosis. The aim of this study was to investigate the tolerability and pharmacokinetics of HX-1171 in healthy volunteers. METHODS A randomized, single-blind, placebo-controlled, dose escalation study was conducted in 83 subjects. In the single ascending dose study, 20,...
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ژورنال
عنوان ژورنال: Antimicrobial Agents and Chemotherapy
سال: 1995
ISSN: 0066-4804,1098-6596
DOI: 10.1128/aac.39.2.356